Bottom Line - PSA Evolution

PSA vs Time
Date 02/25/95 12/15/97 04/27/99 07/27/99 08/01/99 09/21/99 10/12/99 10/27/99 11/29/99 01/04/00 02/07/00
PSA 1.72 1.9 5.4 diagnosis 6.2 (est) 1.9 1.4* 2.2 2.1 2.4 2.0
Date 03/16/00 04/17/00 06/02/00 07/10/00 08/10/00 09/08/00 09/21/00 10/05/00 11/10/00 12/11/00 01/11/01
PSA 1.8 2.0 2.2 2.3 2.2 3.8* 2.5 2.2 2.2 2.1 2.2
Date 02/15/01 03/01/01 04/05/01 05/09/01 05/11/01 05/25/01 06/06/01 07/11/01 08/14/01 09/10/01 10/09/01
PSA 2.8 2.5 2.6 19.6 14.0 4.0 2.5 2.3 1.91 2.12 1.93
Date 11/08/01 12/11/01 01/09/02 01/11/02 01/15/02 01/21/02 01/29/02 02/05/02 02/13/02 02/22/02 03/28/02
PSA 2.15 2.15 8.64 6.70 5.43 5.45 4.01 2.97 2.43 2.51 2.49
Date 04/29/02 05/28/02 06/24/02 07/22/02 08/20/02 09/26/02 11/04/02 12/10/02 01/27/03 02/05/03 03/11/03
PSA 2.15 2.08 2.07 2.16 2.08 1.96 2.37 2.08 2.59 2.40 1.95
Date 04/22/03 06/16/03 08/01/03 09/22/03 11/17/03 01/13/04 03/19/04 05/06/04 07/14/04 08/04/04 10/15/04
PSA 1.89 2.18 2.15 2.25 1.88 2.08 2.29 1.91 2.54 2.53 2.17
Date 12/03/04 12/13/04 12/22/04 03/28/05 04/05/05 06/01/05 07/06/05 08/09/05 09/21/05 11/21/05 01/18/06
PSA 6.45 3.37 3.29 5.3 7.43 4.42 18.3 2.44 3.03 2.23 2.37
Free PSA       15 %              
Date 03/06/06 04/18/06 08/14/06 01/22/07 03/05/07 05/07/07 08/22/07 09/28/07 12/18/07 02/14/08 07/07/08
PSA 3.27 4.33 4.78 3.61 4.34
UCSF
3.46 4.62 5.14 3.25 4.00 4.00
Free PSA   16 %                  
Date 09/22/08 02/13/09 06/18/09 11/04/09 03/19/10 10/11/10 02/22/11 06/10/11 11/02/11 03/14/12 07/27/12
PSA 5.86 5.72 5.92 5.00 4.61 4.7 5.84 5.4 5.2 4.7 6.1
Free PSA                      
Date 10/11/12 12/17/12 03/04/13 03/25/14 02/17/15 06/17/15 10/29/15 02/04/16 04/14/16 08/18/16 12/13/16
PSA 7.22
Hunter Labs
6.8 7.3 7.40
Hunter Labs
8.1 8.8 7.8 10.5 8.2 9.9 9.7
Free PSA     21 %   17 % 15.9 %          
Date 03/02/17 05/31/17 09/11/17 12/07/17 02/13/18 05/16/18 11/09/18 04/17/19 06/03/19 10/31/19 02/24/20
PSA 11.5 10.0 8.1 8.6 10.2 7.68
PAMF
8.2 10.4 9.0 11.1 14.5
Free PSA       20 %           19 %  
Date 06/10/20 12/03/20 03/15/21 06/04/21              
PSA 13.1 12.4 12.5 9.9              
Free PSA                      
The estimate comes from a linear model ==> 3.5/16 months = 0.21875/month
* 4 months (May - Aug) = 0.875
==> Aug PSA ~ 6.2
 
Diagnosis: T1c, Gleason 3+3, no symptoms, no cancer found by DRE, TRUS; only in 2 of 14 biopsy cores; some cancer found in 1 Sep 1999 MRI Spectroscopy
 
Graphical Image of PSA vs Time
 
Note that PSA reliability/reproducibility/variability is about +/- 10-15%
 
See the discussion in the full document ( http://www.cohensw.com/mvpcsg_nov99_text.html
)
The anomolous values of May 2001, Jan 2002 and the Winter of 2005 are due to bouts of prostatitis.
The gradual rise since 2006 has ben due to BPH.
Unless otherwise noted, all PSA measurements were done at Stanford Hospital
Free PSA < 10% is indicative of cancer, >20% no cancer (for PSA < 10)

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© Copyright 2000-2020, Howard J. Cohen, Ph.D., All Rights Reserved

Created: 26 October 1999
Last updated 04 June 2021
Author: Howard J. Cohen
Copyright © 1999-2021, Howard J Cohen, All Rights Reserved